NFL.com has the story on the latest with OT Joe Staley:

The San Francisco 49ers confirmed Monday that left tackle Joe Staley will be sidelined for a significant period of time with a knee injury suffered in Sunday’s 18-14 loss to the Indianapolis Colts. Staley suffered sprains to two ligaments — the MCL and PCL — in his right knee and will be sidelined for six weeks. Staley had an MRI exam on his knee to determine the damage.